Marguerite de Béthune (1595 – 21 October 1660) was the daughter of Maximilien, Duke of Sully and his second wife Rachel de Cochefilet.
She married Henri de Rohan on 7 February 1603, and was then known as the Duchess consort of Rohan. Their only child Marguerite inherited the duchy and became Duchess of Rohan suo jure.